Estimation of the activation and kinetic properties of I-Na and I-K from the time course of the action potential

Toth, T. I. and Crunelli, Vincenzo ORCID: https://orcid.org/0000-0001-7154-9752 2001. Estimation of the activation and kinetic properties of I-Na and I-K from the time course of the action potential. Journal of Neuroscience Methods 111 (2) , pp. 111-126. 10.1016/S0165-0270(01)00433-2

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Abstract

A detailed knowledge of the quantitative properties of the currents INa and IKunderlying the action potential is essential for a deeper understanding of neuronal excitatory processes. However, it is not always possible or practical to perform voltage-clamp measurements that usually provide the necessary data. In this paper, we present a method by which the activation and kinetic properties of these currents can be estimated from current-clamp data, more precisely from the time course of the action potential, provided some additional electrophysiological properties of the neurone are a priori known. We report results from thalamocortical neurones and a cortical pyramidal cell, and suggest that the method will work with other types of neurones, if their action potentials are primarily shaped by INa and IK.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Neuroscience and Mental Health Research Institute (NMHRI)
Publisher:	Elsevier
ISSN:	0165-0270
Last Modified:	25 Oct 2022 10:05
URI:	https://orca.cardiff.ac.uk/id/eprint/61104

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