Synthesis and properties of novel chemiluminescent biological probes: 2- and 3-(2-Succinimidyloxycarbonylethyl)phenyl acridinium esters

Smith, Keith., Yang, Jing-Jing, Li, Zhaoqiang, Weeks, Ian ORCID: https://orcid.org/0000-0002-6362-2929 and Woodhead, J. Stuart 2009. Synthesis and properties of novel chemiluminescent biological probes: 2- and 3-(2-Succinimidyloxycarbonylethyl)phenyl acridinium esters. Journal of Photochemistry and Photobiology A: Chemistry 203 (1) , pp. 72-79. 10.1016/j.jphotochem.2008.12.020

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Abstract

Five new chemiluminescent aryl acridiniumcarboxylate esters 6–10, with a linker group in an ortho- or meta-position of the phenoxy ring, have been synthesized. The ortho- derivatives 6, 7 and 9 show significant improvement in the quantum yield of chemiluminescence and slower chemiluminescence kinetics compared to the unsubstituted para- derivative, 1, while the ortho- derivative 8 shows quicker chemiluminescence kinetics and a lower quantum yield of chemiluminescence. The meta- derivative 10 shows similar chemiluminescent properties to that of its para-substituted analogue.

Item Type:	Article
Status:	Published
Schools:	Chemistry Medicine Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QD Chemistry
Uncontrolled Keywords:	Acridinium ester; Chemiluminescence; Chemiluminescence immunoassay
Publisher:	Elsevier
ISSN:	1010-6030
Date of First Compliant Deposit:	30 March 2016
Last Modified:	19 May 2023 15:55
URI:	https://orca.cardiff.ac.uk/id/eprint/6126

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