Endoplasmic reticulum calcium tunnels integrate signalling in polarised cells

Petersen, Ole Holger ORCID: https://orcid.org/0000-0002-6998-0380 and Verkhratsky, A. 2007. Endoplasmic reticulum calcium tunnels integrate signalling in polarised cells. Cell Calcium 42 (4-5) , pp. 373-378. 10.1016/j.ceca.2007.05.012

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Abstract

One of the most crucial aspects of Ca2+ signalling is the ability to generate highly localised transient elevations of the cytosolic Ca2+ concentration at specific strategically important target sites. Inevitably this necessitates a relatively high Ca2+ buffering power of the cytoplasm, which in turn makes movement of Ca2+ from one part of a cell to another difficult. Nature has evolved an elegant solution to this problem by creating operational Ca2+ tunnels through the endoplasmic reticulum. Very recently direct evidence that such tunnelling also occurs in neurons has been provided.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Systems Immunity Research Institute (SIURI)
Publisher:	Elsevier
ISSN:	0143-4160
Last Modified:	25 Oct 2022 10:10
URI:	https://orca.cardiff.ac.uk/id/eprint/61323

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