Caspase-dependent proteolytic cleavage of STAT3a in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines

Matthews, James, Watson, Susan M. R., Tevendale, Maxine C. L., Watson, Christine J. and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2007. Caspase-dependent proteolytic cleavage of STAT3a in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines. BMC Cancer 7 (29) , pp. 1-12. 10.1186/1471-2407-7-29

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Abstract

The STAT (Signal Transducers and Activators of Transcription) transcription factor family mediates cellular responses to a wide range of cytokines. Activated STATs (particularly STAT3) are found in a range of cancers. Further, STAT3 has anti-apoptotic functions in a range of tumour cell lines. After observing a proteolytic cleavage in STAT3α close to a potential apoptotic caspase protease cleavage site we investigated whether STAT3α might be a caspase substrate

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Additional Information:	PDF uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/1471-2407/ [accessed 16/10/14]
Publisher:	BioMed Central
ISSN:	1471-2407
Date of First Compliant Deposit:	30 March 2016
Last Modified:	12 May 2023 17:06
URI:	https://orca.cardiff.ac.uk/id/eprint/61423

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