In situ randomised trial to investigate the occluding properties of two desensitising toothpastes on dentine after subsequent acid challenge

Seong, Joon, Macdonald, E., Newcombe, Robert Gordon ORCID: https://orcid.org/0000-0003-4400-8867, Davies, M., Jones, S. B., Johnson, S. and West, N. X. 2013. In situ randomised trial to investigate the occluding properties of two desensitising toothpastes on dentine after subsequent acid challenge. Clinical Oral Investigations 17 (1) , pp. 195-203. 10.1007/s00784-012-0683-7

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Abstract

Objectives: The aim of the study was to determine in situ the relative abilities of two desensitising toothpastes to occlude dentinal tubules with or without acid challenge. Materials and methods: The study design was a single centre, randomised, split mouth crossover model examining four treatments over two periods. The primary outcome was the degree of occlusion proffered by two desensitising toothpastes [Sensodyne® Rapid Relief (8% strontium acetate, 1040 ppm sodium fluoride) and Colgate® Sensitive Pro-ReliefTM daily (8% arginine, 1450 ppm sodium monofluorophosphate)], a standard toothpaste (1450 ppm sodium fluoride) and water, after acid challenge. Healthy adult volunteers wore bi-lateral lower buccal appliances each with two dentine sections, receiving two treatments per study period. Samples were brushed twice a day with treatment, with two additional 3-min extra-oral acidic challenges applied ex vivo on days 3 and 4. A secondary outcome was the degree of occlusion attained in the absence of acid challenge. Examiners blinded to the study assessed occlusion by visual score of post-treatment scanning electron microscope images. Results: All 28 participants completed the study. In the absence of acid challenge, occlusion scores for both desensitising toothpastes were similar and significantly better than control scores (p < 0.02). After acid challenge both desensitising toothpastes occluded more effectively than controls; however, occlusion scores for the strontium acetate paste were significantly greater than those of the arginine paste (p < 0.02). Conclusions: The occluding properties of the strontium acetate toothpaste were significantly more robust after acid challenge than those of the arginine toothpaste. Clinical relevance: Patients with hypersensitivity, regularly imbibing dietary acidic drinks, should be advised that Sensodyne® Rapid Relief provides robust tubule occlusion despite repeated acidic challenges.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > RK Dentistry
Uncontrolled Keywords:	Dentine hypersensitivity; Dentine erosion; Toothpaste; Clinical study in situ; Dentine abrasion
Publisher:	Springer Verlag
ISSN:	1432-6981
Last Modified:	23 Oct 2025 12:30
URI:	https://orca.cardiff.ac.uk/id/eprint/61473

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