Kinase cogs go forward and reverse in the Wnt signaling machine

Dale, Trevor Clive ORCID: https://orcid.org/0000-0002-4880-9963 2006. Kinase cogs go forward and reverse in the Wnt signaling machine. Nature Structural & Molecular Biology 13 (1) , pp. 9-11. 10.1038/nsmb0106-9

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Abstract

An important link between Wnt binding at the cell surface and nuclear -catenin–TCF–dependent transcription has been made with the identification of kinases that promote the association of the Wnt receptor and -catenin turnover complexes. Surprisingly, the enzymes implicated had previously been suggested to inhibit rather than promote Wnt signaling.

Item Type:	Article
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Publisher:	Nature Publishing Group
ISSN:	1545-9993
Funders:	CR-UK
Last Modified:	22 Jun 2023 10:01
URI:	https://orca.cardiff.ac.uk/id/eprint/61751

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