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Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1)

Raybould, Rachel, Green, Elaine K., MacGregor, Stuart, Gordon-Smith, Katherine, Heron, Jess, Hyde, Sally, Caesar, Sian, Nikolov, Ivan, Williams, Nigel Melville, Jones, Lisa, O'Donovan, Michael Conlon, Owen, Michael John, Jones, Ian Richard, Kirov, George and Craddock, Nicholas John 2005. Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1). Biological psychiatry 57 (7) , pp. 696-701. 10.1016/j.biopsych.2005.01.018

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Background: Several studies support the dysbindin (dystrobrevin binding protein 1) gene (DTNBP1) as a susceptibility gene for schizophrenia. We previously reported that variation at a specific 3-locus haplotype influences susceptibility to schizophrenia in a large United Kingdom (UK) Caucasian case-control sample. Methods: Using similar methodology to our schizophrenia study, we have investigated this same 3-locus haplotype in a large, well-characterized bipolar sample (726 Caucasian UK DSM-IV bipolar I patients; 1407 ethnically matched controls). Results: No significant differences were found in the distribution of the 3-locus haplotype in the full sample. Within the subset of bipolar I cases with predominantly psychotic episodes of mood disturbance (n = 133) we found nominally significant support for association at this haploptype (p< .042) and at SNP rs2619538 (p= .003), with a pattern of findings similar to that in our schizophrenia sample. This finding was not significant after correction for multiple testing. Conclusions: Our data suggest that variation at the polymorphisms examined does not make a major contribution to susceptibility to bipolar disorder in general. They are consistent with the possibility that DTNBP1 influences susceptibility to a subset of bipolar disorder cases with psychosis. However, our subset sample is small and the hypothesis requires testing in independent, adequately powered samples.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 0006-3223
Last Modified: 16 Mar 2020 14:22

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