A scaleable and defined system for generating neural stem cells from human embryonic stem cells

Joannides, Alexis J., Fiore-Hériché, Christelle, Battersby, Alysia A., Athauda-Arachchi, Pandula, Bouhon, Isabelle A., Williams, Lydia, Westmore, Kristine, Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X, Compston, Alastair, Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and Chandran, Siddharthan 2006. A scaleable and defined system for generating neural stem cells from human embryonic stem cells. Stem Cells 25 (3) , pp. 731-737. 10.1634/stemcells.2006-0562

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Abstract

The ability to differentiate human ESCs (hESCs) to defined lineages in a totally controlled manner is fundamental to developing cell-based therapies and studying human developmental mechanisms. We report a novel, scaleable, and widely applicable system for deriving and propagating neural stem cells from hESCs without the use of animal products, proprietary formulations, or genetic manipulation. This system provides a definitive platform for studying human neural development and has potential therapeutic implications.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Neuroscience and Mental Health Research Institute (NMHRI)
Publisher:	AlphaMed Press
ISSN:	1066-5099
Last Modified:	27 Oct 2022 08:25
URI:	https://orca.cardiff.ac.uk/id/eprint/62260

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