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Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation

Baudouin, Stephane J., Pujol, Fabien, Nicot, Arnaud, Kitabgi, Patrick and Boudin, Hélène 2006. Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation. Molecular and Cellular Neuroscience 33 (2) , pp. 160-169. 10.1016/j.mcn.2006.07.007

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The chemokine SDF-1 is a secreted protein that plays a critical role in several aspects of neuron development through interaction with its unique receptor CXCR4. A key mechanism that controls neuron responsiveness to extracellular signals during neuronal growth is receptor endocytosis. Since we previously reported that SDF-1 regulates axon development without affecting the other neurites, we asked whether this could correlate with a compartment-selective trafficking of CXCR4. We thus studied CXCR4 behavior upon SDF-1 exposure in rat hippocampus slices and in transfected neuron cultures. A massive agonist-induced redistribution of CXCR4 in endosomes was observed in dendrites whereas no modification was evidenced in axons. Our data suggest that CXCR4 trafficking may play a role in mediating selective effects of SDF-1 on distinct neuronal membrane subdomains.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history
Q Science > QH Natural history > QH426 Genetics
Uncontrolled Keywords: Trafficking; Endocytosis; Hippocampal neuron; Chemokine; Development; G-protein-coupled receptor
Publisher: Elsevier
ISSN: 1044-7431
Last Modified: 04 Jun 2017 06:34

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