Fear memory retrieval induces CREB phosphorylation and Fos expression within the amygdala

Hall, Jeremy ORCID: https://orcid.org/0000-0003-2737-9009, Thomas, Kerrie Lorraine ORCID: https://orcid.org/0000-0003-3355-9583 and Everitt, Barry J. 2001. Fear memory retrieval induces CREB phosphorylation and Fos expression within the amygdala. European Journal of Neuroscience 13 (7) , pp. 1453-1458. 10.1046/j.0953-816x.2001.01531.x

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Abstract

Fear memory retrieval has been shown to induce a protein-synthesis dependent re-consolidation of memories within the amygdala. Here, using immunocytochemistry, we investigated the molecular basis of this process in the rat and show that retrieval of a cued fear memory induces the activation, by phosphorylation, of the transcription factor CREB within the basal and lateral nuclei of the amygdala, as well as expression of the CREB-regulated immediate-early gene, c-fos, in the basal amygdala. We also show an increase in CREB phosphorylation within the central nucleus of the amygdala following behavioural testing, with an accompanying increase in Fos-immunoreactive nuclei in animals retrieving the cued association. There were no changes in either phosphorylated CREB or Fos in the hippocampus following exposure to discrete fear stimuli. These results show that activation of CREB, which has been shown to be involved in the formation of long-term fear memories, also accompanies memory retrieval, and also suggest a role for CREB phosphorylation in memory re-consolidation following retrieval

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > QH Natural history > QH426 Genetics
Uncontrolled Keywords:	gene expression; hippocampus; learning and memory; rat
Publisher:	Wiley
ISSN:	0953-816X
Last Modified:	27 Oct 2022 08:28
URI:	https://orca.cardiff.ac.uk/id/eprint/62415

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