Some antidepressant agents (Li+, monoamine oxidase type A inhibitors) perturb the ultradian clock in Saccharomyces cerevisiae

Salgado, Eshantha, Murray, Douglas B. and Lloyd, David ORCID: https://orcid.org/0000-0002-5656-0571 2002. Some antidepressant agents (Li+, monoamine oxidase type A inhibitors) perturb the ultradian clock in Saccharomyces cerevisiae. Biological Rhythm Research 33 (3) , pp. 351-361. 10.1076/brhm.33.3.351.8256

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Abstract

A continuous culture of Saccharomyces cerevisiae shows continuous autonomous oscillatory behaviour: this system is controlled by an ultradian clock. We used the most convenient observable (dissolved O 2) to assess the effects of various psychotropic agents on the period (t) and waveform of the oscillation. The threshold for a measurable perturbation by LiCl was between 10µM and 100µM; the value of t was increased from the normal 40 min to 50 min. Higher concentrations (up to 800µM), gave a dose-dependent period lengthening response to 68 min. At higher doses, the oscillation showed an abrupt transition to a state of higher complexity, where t ? 5 h. Recovery was also dose-dependent; this took 8 h at 100µM or 36 h at 600µM: at 1.2mM Li + organisms never recovered to a stable oscillatory state. Very high concentrations of inhibitors of monoamine oxidase type A + B (Phenelzine) or type A (Iproniazid) led to immediate period lengthening. The type B inhibitor (Pargyline) gave no detectable effect. Melatonin (1.5 mM), serotonin (1.5mM) dopamine (5 mM) or tyramine (2.5mM) were also without effect. The addition of glutamate perturbed the oscillation but did not cause a transient period lengthening.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Taylor & Francis
ISSN:	0929-1016
Last Modified:	27 Oct 2022 08:34
URI:	https://orca.cardiff.ac.uk/id/eprint/62686

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