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Cell death mechanisms in the human opportunistic pathogen Candida albicans

Lemar, Katey M., Muller, Carsten Theodor, Plummer, Susan and Lloyd, David 2003. Cell death mechanisms in the human opportunistic pathogen Candida albicans. Journal of Eukaryotic Microbiology 50 (s1) , pp. 685-686. 10.1111/j.1550-7408.2003.tb00687.x

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Difficulties arising during chemotherapy of Candida albicans necessitate novel chemotherapeutic strategies. Garlic extract and two of its constituents, diallyl disulphide and allyl alcohol, are potentially useful anti-candidal agents. Flow Cytometry has been used to measure the population distributions of apoptotic/necrotic cell death using annexin V-FITC/propidium iodide and oxidative stress dichlorodihydrofluorescein. Candicidal mechanisms may be due to programmed cell death induced by oxidative stress, mediated by the generation of reactive oxygen species or alternatively by the depletion of cellular thiols, which normally act as redox buffer systems for defence. We suggest that mechanisms that these anti-candidal agents have in common is the triggering some of the characteristics of apoptotic cell death.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Uncontrolled Keywords: Apoptosis; cellular thiols; garlic; necrosis; oxidative stress; yeast
Publisher: Wiley-Blackwell
ISSN: 1066-5234
Last Modified: 04 Jun 2017 06:37

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