SoxB transcription factors specify neuroectodermal lineage choice in ES cells

Zhao, Suling, Nichols, Jennifer, Smith, Austin G. and Li, Meng ORCID: https://orcid.org/0000-0002-4803-4643 2004. SoxB transcription factors specify neuroectodermal lineage choice in ES cells. Molecular and Cellular Neuroscience 27 (3) , pp. 332-342. 10.1016/j.mcn.2004.08.002

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Abstract

Knowledge of lineage decision machinery in pluripotent embryonic stem (ES) cells may shed light on the process of germ layer segregation in the mammalian embryo and enable directed differentiation in vitro for biomedical applications. We have investigated the contribution of Class B1 Sox transcription factors to lineage choice during ES cell differentiation. We report that forced expression of Sox1 or Sox2 did not impair propagation of undifferentiated ES cells, but upon release from self-renewal promoted differentiation into neuroectoderm at the expense of mesoderm and endoderm. The efficient specification of a primary lineage by transcription factor manipulation provides a paradigm for instructing differentiation of ES cells for biopharmaceutical screening and cell therapy applications.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine
Subjects:	Q Science > Q Science (General)
Publisher:	Elsevier
ISSN:	1044-7431
Last Modified:	27 Oct 2022 08:41
URI:	https://orca.cardiff.ac.uk/id/eprint/63103

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