Kirov, George  ORCID: https://orcid.org/0000-0002-3427-3950, Jones, Ian Richard ORCID: https://orcid.org/0000-0001-5821-5889, McCandless, F., Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610 and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862
1999.
Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5.
Molecular Psychiatry
4
(6)
, pp. 558-565.
|
Abstract
The dopaminergic system has been implicated in the aetiology of mood disorders. We conducted family-based association studies for polymorphisms at three genes involved in the metabolism of dopamine: dopamine transporter (DAT1), dopamine-beta-hydroxylase (DBH) and catechol-O-methyl transferase (COMT); and three dopamine receptors: DRD2, DRD3 and DRD5. We used a sample of 122 parent-offspring trios of British Caucasian origin where the proband had bipolar disorder I (BPI), and analysed the results with the transmission/disequilibrium test (TDT) which is robust to hidden population stratification. No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII) |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine |
| Publisher: | Nature Publishing Group |
| ISSN: | 1359-4184 |
| Related URLs: | |
| Last Modified: | 27 Oct 2022 08:41 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/63114 |
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