Localization and regulation of Ca2+ entry and exit pathways in exocrine gland cells

Petersen, Ole Holger ORCID: https://orcid.org/0000-0002-6998-0380 2003. Localization and regulation of Ca2+ entry and exit pathways in exocrine gland cells. Cell Calcium 33 (5-6) , pp. 337-344. 10.1016/S0143-4160(03)00047-2

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Abstract

Studies of Ca2+ transport pathways in exocrine gland cells have been useful, chiefly because of the polarized nature of the secretory epithelial cells. In pancreatic acinar cells, for example, Ca2+ reloading of empty intracellular stores can occur solely via Ca2+ entry through the basal part of the plasma membrane. On the other hand, the principal site for intracellular Ca2+ release—with the highest concentration of inositol 1,4,5-trisphosphate (IP3) receptors—is in the apical secretory pole close to the apical plasma membrane. This apical part of the plasma membrane contains the highest density of Ca2+ pumps and is therefore the principal site for Ca2+ extrusion. On the basis of the known properties of Ca2+ entry and exit pathways in exocrine gland cells, the mechanisms controlling Ca2+ exit and entry are discussed in relation to recent direct information about Ca2+ transport into and out of the endoplasmic reticulum (ER) and the mitochondria in these cells.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Systems Immunity Research Institute (SIURI)
Uncontrolled Keywords:	Endoplasmic reticulum; Ca2+ entry; Ca2+ exit; Exocrine gland cells
ISSN:	0143-4160
Last Modified:	27 Oct 2022 08:42
URI:	https://orca.cardiff.ac.uk/id/eprint/63144

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