Spatial characterisation of ryanodine-induced calcium release in mouse pancreatic acinar cells

Ashby, Michael C., Petersen, Ole Holger ORCID: https://orcid.org/0000-0002-6998-0380 and Tepikin, Alexei V. 2003. Spatial characterisation of ryanodine-induced calcium release in mouse pancreatic acinar cells. Biochemical Journal 369 (3) , pp. 441-445. 10.1042/BJ20021039

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Abstract

In pancreatic acinar cells, agonists evoke intracellular Ca2+ transients which are initiated in the apical region of these polarized cells. There are contradictory experimental data concerning Ca2+ release from ryanodine receptors (RyRs) in the apical region. In the present study, we have used low doses of ryanodine to open RyRs leading to the release of Ca2+ from intracellular stores. Ryanodine causes Ca2+ release that is initiated in the apical region of the cell but is dependent upon functional inositol 1,4,5-trisphosphate receptors (IP3Rs). These results suggests that co-ordinated release from co-localized RyRs and IP3Rs underlies the increased sensitivity of the apical region to initiation of intracellular Ca2+ transients.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Systems Immunity Research Institute (SIURI)
Uncontrolled Keywords:	calcium wave, exocrine, pancreatic acinar cell, receptor localization, ryanodine receptor
Publisher:	Biochemical Society
ISSN:	0264-6021
Last Modified:	27 Oct 2022 08:42
URI:	https://orca.cardiff.ac.uk/id/eprint/63147

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