Block in development at the pre-B-II to immature B cell stage in mice without lgk and iga light chain

Zou, Xiangang, Piper, Tony A., Smith, J. A., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Xian, Jian and Bruggemann, Marianne 2003. Block in development at the pre-B-II to immature B cell stage in mice without lgk and iga light chain. The Journal of Immunology 170 (3) , pp. 1354-1361.

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Abstract

Silencing individual C (constant region) lambda genes in a kappa(-/-) background reduces mature B cell levels, and L chain-deficient (lambda(-/-)kappa(-/-)) mice attain a complete block in B cell development at the stage when L chain rearrangement, resulting in surface IgM expression, should be completed. L chain deficiency prevents B cell receptor association, and L chain function cannot be substituted (e.g., by surrogate L chain). Nevertheless, precursor cell levels, controlled by developmental progression and checkpoint apoptosis, are maintained, and B cell development in the bone marrow is fully retained up to the immature stage. L chain deficiency allows H chain retention in the cytoplasm, but prevents H chain release from the cell, and as a result secondary lymphoid organs are B cell depleted while T cell levels remain normal.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > Q Science (General)
Publisher:	Wiley Blackwell
ISSN:	0019-2805
Last Modified:	27 Oct 2022 08:49
URI:	https://orca.cardiff.ac.uk/id/eprint/63495

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