Bipolar affective puerperal psychosis associated with consanguinity

Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610, Brockington, I., Mant, R., Parfitt, E., McGuffin, P. and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 1994. Bipolar affective puerperal psychosis associated with consanguinity. British Journal of Psychiatry 164 (3) , pp. 359-364. 10.1192/bjp.164.3.359

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Abstract

Most clinical and genetic evidence suggests that puerperal psychosis is closely related to bipolar affective disorder. During a linkage study of bipolar disorder we ascertained a British family in which puerperal psychosis was associated with consanguinity in three sisters. All three subjects had lifetime RDC diagnoses of bipolar I or manic disorder. An inbred brother also had bipolar I disorder. The only female member of the sibship to escape puerperal psychosis was outbred. These findings are consistent with several genetic models for bipolar disorder in this family. The most interesting possibility is a single major susceptibility locus of recessive effect. Under this assumption, the family could be used for homozygosity mapping to help localise the putative recessive locus. If other inbred families can be found in which the same putative recessive locus is operating, the power to localise the gene by homozygosity mapping would be greatly increased.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Publisher:	Royal College of Psychiatrists
ISSN:	0007-1250
Last Modified:	27 Oct 2022 08:50
URI:	https://orca.cardiff.ac.uk/id/eprint/63509

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