Genomic organisation and characterisation of the neural sex-determination gene fruitless (fru) in the Hawaiian species Drosophila heteroneura

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Kurihara, Joyce and Yamamoto, Daisuke 2000. Genomic organisation and characterisation of the neural sex-determination gene fruitless (fru) in the Hawaiian species Drosophila heteroneura. Gene 246 (1-2) , pp. 143-149. 10.1016/S0378-1119(00)00064-0

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Abstract

There are several mechanisms for the determination of sex. Sexual behaviour is part of the sex-determination cascade, and in Drosophila melanogaster male courtship is controlled in part by the fruitless gene. As part of a study of sexual behaviour in Hawaiian Drosophila, we have cloned the neural sex-determination gene fru from the Hawaiian picture-wing species Drosophila heteroneura. The fru gene has at least seven exons covering a region of 18 kb and encodes three transcripts, fruA, fruB and fruC. Each transcript encodes a single ORF of 841, 678 and 691 aa, respectively. The FRUA and FRUB proteins have a BTB protein–protein-binding domain and two zinc finger-like domains and are well conserved with the D. melanogaster proteins. The FRUC protein has a BTB domain but no zinc finger-like domains. The fru gene is expressed in 1–7 day old adult males as a 5.1 kb transcript. This transcript is not seen in adult females, so the fru gene has a different pattern of sex-differential expression in the Hawaiian Drosophila compared with D. melanogaster.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > R Medicine (General)
Uncontrolled Keywords:	bp, base pairs; BTB protein–protein-binding domain; DNA cloning; kb, 1000-base pairs; Muscle of Lawrence; Sexual behaviour; Transcription factor; Zinc finger domain
Publisher:	Elsevier
ISSN:	0378-1119
Last Modified:	14 Dec 2022 07:22
URI:	https://orca.cardiff.ac.uk/id/eprint/63564

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