CpG deficiency, dinucleotide distributions and nucleosome positioning

Adams, Roger L. P., Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Rinaldi, Angela and Eason, Robert 1987. CpG deficiency, dinucleotide distributions and nucleosome positioning. European Journal of Biochemistry 165 (1) , pp. 107-115. 10.1111/j.1432-1033.1987.tb11200.x

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Abstract

The dinucleotide CpG is deficient in (A + T)-rich regions of vertebrate DNA in both coding and non-coding sequences and there is a corresponding increase above expectation in the occurrence of TpG and CpA. By contrast in (G + C)-rich regions no deficiency of CpG is found. Such (G + C)-rich sequences, containing the expected number of CpG dinucleotides, alternate along the genome with (A + T)-rich sequences which have a lower than expected CpG content. The G + C content of vertebrate DNA can oscillate with a period of 150–200 bp and this may be a factor in positioning nucleosomes. The role of mutagenesis in loss of CpG and increase of A + T, particularly in non-coding regions, is discussed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > R Medicine (General)
Publisher:	Wiley
ISSN:	0014-2956
Last Modified:	14 Dec 2022 07:23
URI:	https://orca.cardiff.ac.uk/id/eprint/63602

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