Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis

Atincicek, B., Moll, J., Campos, N., Foerster, G., Beck, E., Hoeffler, J. F., Grosdemange-Billiard, C., Rodriguez-Concepcion, M., Rohmer, M., Boronat, A., Eberl, Matthias ORCID: https://orcid.org/0000-0002-9390-5348 and Jomaa, H. 2001. Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. The Journal of Immunology 166 (6) , pp. 3655-3658. 10.4049/jimmunol.166.6.3655

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Abstract

Activation of V gamma 9/V delta 2 T cells by small nonprotein Ags is frequently observed after infection with various viruses, bacteria, and eukaryotic parasites. We suggested earlier that compounds synthesized by the 2-C:-methyl-D-erythritol 4-phosphate (MEP) pathway of isopentenyl pyrophosphate synthesis are responsible for the V gamma 9/V delta 2 T cell reactivity of many pathogens. Using genetically engineered Escherichia coli knockout strains, we now demonstrate that the ability of E. coli extracts to stimulate gamma delta T cell proliferation is abrogated when genes coding for essential enzymes of the MEP pathway, dxr or gcpE, are disrupted or deleted from the bacterial genome.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Publisher:	American Association of Immunologists
ISSN:	0022-1767
Last Modified:	27 Oct 2022 09:01
URI:	https://orca.cardiff.ac.uk/id/eprint/64137

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