A hookworm allergen which strongly resembles calreticulin

Pritchard, D. I., Brown, Alan, Kasper, Grit, Mcelroy, Paul, Loukas, Alex, Hewitt, Colin, Berry, Colin ORCID: https://orcid.org/0000-0002-9943-548X, Fullkrug, Ralf and Beck, Ewald 1999. A hookworm allergen which strongly resembles calreticulin. Parasite Immunology 21 (9) , pp. 439-450. 10.1046/j.1365-3024.1999.00238.x

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Abstract

Immmoglobulin E-rich plasma from patients from Papua New Guinea infected with Necator americanus has been used to probe an adult N. americanus cDNA library for the presence of hookworm allergens. Using this approach, one hookworm allergen has been identified as calreticulin, which was subsequently expressed in Escherichia coli. Little serological cross reactivity was seen between the recombinant calreticulins of this hookworm and its host. Prospective roles for hookworm calreticulin in the host-parasite relationship are discussed in depth.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Wiley
ISSN:	0141-9838
Last Modified:	27 Oct 2022 09:13
URI:	https://orca.cardiff.ac.uk/id/eprint/64824

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