Symptoms of irritable bowel syndrome in patients with inflammatory bowel disease: examining the role of sub-clinical inflammation and the impact on clinical assessment of disease activity

Berrill, J. W., Green, John, Hood, Kerenza ORCID: https://orcid.org/0000-0002-5268-8631 and Campbell, Anthony Keith 2013. Symptoms of irritable bowel syndrome in patients with inflammatory bowel disease: examining the role of sub-clinical inflammation and the impact on clinical assessment of disease activity. Alimentary Pharmacology and Therapeutics 38 (1) , pp. 44-51. 10.1111/apt.12335

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Abstract

Background: Symptoms compatible with irritable bowel syndrome (IBS) are frequently present in patients with inflammatory bowel disease (IBD); however, the cause of this phenomenon is unclear. Aim: To determine the different contributions of ‘true IBS’ and sub-clinical inflammation in producing IBS-type symptoms in IBD patients, and to ascertain the impact these symptoms have on the clinical assessment of IBD activity. Methods: In this cross-sectional study, 169 IBD patients completed questionnaires to assess disease activity, presence of IBS-type symptoms, and levels of anxiety and depression. Stool samples were collected for analysis of faecal calprotectin (FC). Results: IBS-type symptoms were significantly more common in female patients (OR = 4.64, 1.55–13.88) and were associated with higher levels of anxiety (OR = 1.11, 1.01–1.21). There was no statistical difference between the FC levels of patients in clinical remission with IBS-type symptoms compared with those without (median values = 111 μg/g vs. 45.5 μg/g respectively, P = 0.171). The prevalence of IBS-type symptoms in patients with a normal FC level was 31%. Conclusions A substantial number of IBD patients with normal faecal calprotectin level experience IBS-type symptoms. These patients exhibit similar features to people diagnosed with IBS in the general community, suggesting that the conditions are not mutually exclusive and may coexist in a considerable number of IBD patients. A systematic diagnostic approach is required to assess IBD patients with IBS-type symptoms as sub-clinical inflammation may play a role in a proportion of cases.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Pharmacy
Subjects:	R Medicine > RC Internal medicine R Medicine > RS Pharmacy and materia medica R Medicine > RZ Other systems of medicine
Uncontrolled Keywords:	Adult; Anxiety; Cross-Sectional Studies; Depression; Disease Progression; Female; Humans; Inflammation; Inflammatory Bowel Diseases; Irritable Bowel Syndrome; Male; Middle Aged; Questionnaires; Severity of Illness Index
Publisher:	Wiley-Blackwell
ISSN:	0269-2813
Last Modified:	27 Oct 2022 09:24
URI:	https://orca.cardiff.ac.uk/id/eprint/65523

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