Immunology of human papillomavirus infection in lower genital tract neoplasia [review]

Man, Stephen Tzekwung ORCID: https://orcid.org/0000-0001-9103-1686 and Fiander, Alison Nina 2001. Immunology of human papillomavirus infection in lower genital tract neoplasia [review]. Best Practice & Research Clinical Obstetrics & Gynaecology 15 (5) , pp. 701-714. 10.1053/beog.2001.0215

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Abstract

Despite its being a relatively common virus, the study of human papillomavirus infection has lagged behind that of other viruses. Human papillomaviruses do not provoke strong systemic antibody or T-cell responses. Furthermore, the majority of those infected do not display clinical symptoms and are able to clear the virus by unknown mechanisms. In the last decade, however, research into human papillomavirus immunology has blossomed, for two main reasons. First, there is strong circumstantial evidence that the immune system can control papillomavirus infection, since the prevalence of human papillomavirus-associated neoplasia is increased in immunocompromised individuals. Second, the strong association between human papillomavirus infection and cervical cancer has led to attempts to develop prophylactic or therapeutic vaccines. In this chapter, our current knowledge of human papillomavirus immune responses will be reviewed, and how this relates to clinical practice will be discussed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Publisher:	Elsevier
ISSN:	1521-6934
Last Modified:	27 Oct 2022 09:45
URI:	https://orca.cardiff.ac.uk/id/eprint/67627

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