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The JAK/STAT pathway is involved in synaptic plasticity

Nicolas, Céline S., Peineau, Stéphane, Amici, Mascia, Csaba, Zsolt, Fafouri, Assia, Javalet, Charlotte, Collett, Valerie J., Hildebrandt, Lars, Seaton, Gillian, Choi, Sun-Lim, Sim, Su-Eon, Bradley, Clarrisa, Lee, Kyungmin, Zhuo, Min, Kaang, Bong-Kiun, Gressens, Pierre, Dournaud, Pascal, Fitzjohn, Stephen M., Bortolotto, Zuner A., Cho, Kwangwook and Collingridge, Graham L. 2012. The JAK/STAT pathway is involved in synaptic plasticity. Neuron 73 (2) , pp. 374-390. 10.1016/j.neuron.2011.11.024

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Abstract

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RM Therapeutics. Pharmacology
Publisher: Elsevier
ISSN: 0896-6273
Last Modified: 04 Jun 2017 07:46
URI: https://orca.cardiff.ac.uk/id/eprint/67831

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