Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary history

Zhou, Xuming, Wang, Boshi, Pan, Qi, Zhang, Jinbo, Kumar, Sudhir, Sun, Xiaoqing, Liu, Zhijin, Pan, Huijuan, Lin, Yu, Liu, Guangjian, Zhan, Wei, Li, Mingzhou, Ren, Baoping, Ma, Xingyong, Ruan, Hang, Cheng, Chen, Wang, Dawei, Shi, Fanglei, Hui, Yuanyuan, Tao, Yujing, Zhang, Chenglin, Zhu, Pingfen, Xiang, Zuofu, Jiang, Wenkai, Chang, Jiang, Wang, Hailong, Cao, Zhisheng, Jiang, Zhi, Li, Baoguo, Yang, Guang, Roos, Christian, Garber, Paul A., Bruford, Michael William ORCID: https://orcid.org/0000-0001-6357-6080, Li, Ruiqiang and Li, Ming 2014. Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary history. Nature Genetics 46 (12) , pp. 1303-1310. 10.1038/ng.3137

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Abstract

Colobines are a unique group of Old World monkeys that principally eat leaves and seeds rather than fruits and insects. We report the sequencing at 146× coverage, de novo assembly and analyses of the genome of a male golden snub-nosed monkey (Rhinopithecus roxellana) and resequencing at 30× coverage of three related species (Rhinopithecus bieti, Rhinopithecus brelichi and Rhinopithecus strykeri). Comparative analyses showed that Asian colobines have an enhanced ability to derive energy from fatty acids and to degrade xenobiotics. We found evidence for functional evolution in the colobine RNASE1 gene, encoding a key secretory RNase that digests the high concentrations of bacterial RNA derived from symbiotic microflora. Demographic reconstructions indicated that the profile of ancient effective population sizes for R. roxellana more closely resembles that of giant panda rather than its congeners. These findings offer new insights into the dietary adaptations and evolutionary history of colobine primates.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Biosciences Sustainable Places Research Institute (PLACES)
Subjects:	Q Science > QH Natural history Q Science > QH Natural history > QH426 Genetics
Additional Information:	Published Online 02.11.14.
Publisher:	Nature Publishing Group
ISSN:	1061-4036
Date of First Compliant Deposit:	20 February 2019
Date of Acceptance:	9 October 2014
Last Modified:	06 Jan 2024 03:00
URI:	https://orca.cardiff.ac.uk/id/eprint/68358

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