Supporting physical activity engagement in people with Huntington's disease (ENGAGE-HD): study protocol for a randomized controlled feasibility trial

Busse, Monica ORCID: https://orcid.org/0000-0002-5331-5909, Quinn, Lori ORCID: https://orcid.org/0000-0002-2982-923X, Dawes, Helen, Jones, Carys, Kelson, Mark ORCID: https://orcid.org/0000-0001-7744-3780, Poile, Vincent, Trubey, Robert J., Townson, Julia ORCID: https://orcid.org/0000-0001-8679-3619, Tudor Edwards, Rhiannon, Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753 and Hood, Kerenza ORCID: https://orcid.org/0000-0002-5268-8631 2014. Supporting physical activity engagement in people with Huntington's disease (ENGAGE-HD): study protocol for a randomized controlled feasibility trial. Trials 15 (1) , 487. 10.1186/1745-6215-15-487

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Abstract

Background Huntington's disease (HD) is a complex, single-gene inherited neurodegenerative condition resulting in symptoms that occur across a wide range of neurological domains, including cognitive, behavioral and motor. The benefits of regular physical activity for people with HD are widely recognized. However, a number of factors can prohibit sustained exercise and activity. The purpose of this trial is to explore the feasibility, acceptability and effectiveness of a physical activity intervention program targeted for people with early- to mid-stage HD. Methods The proposed trial is a single blind, multisite, exploratory, randomized controlled feasibility trial of a physical activity intervention. A total of 62 participants with genetically confirmed HD will be recruited. Each participant will be involved in the trial for 26 weeks. Participants will be randomized immediately following the baseline assessment into either a physical activity intervention or a social contact control intervention. The physical activity intervention is framed around self-determination theory placed within a broader Behaviour Change Wheel framework. An HD-specific workbook and individual goal setting will be utilized over six 1:1 sessions, with interim telephone calls. All participants will be reassessed at 16 weeks following the baseline assessment, and then again at a final follow-up assessment 26 weeks later. At the end of the study, all participants will be offered a brief version of the alternative intervention, with one home visit and one follow-up telephone call. Discussion Engaging and supporting people with HD in a regular physical activity program raises a number of challenges. The physical activity intervention and the comparator social interaction intervention have been developed following consultation with people with HD and their families. Each are individually tailored and determined on individual needs and goals. The results from this trial will provide guidance for the development of definitive trials.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Healthcare Sciences Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RT Nursing
Additional Information:	Pdf uploaded in accordance with the publisher’s policy at http://www.sherpa.ac.uk/romeo/issn/1745-6215/ (accessed 05/01/2015)
Publisher:	BioMed Central
ISSN:	1745-6215
Funders:	NISCHR
Date of First Compliant Deposit:	30 March 2016
Last Modified:	27 Jun 2024 01:11
URI:	https://orca.cardiff.ac.uk/id/eprint/68391

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