Fornical and non-fornical projections from the rat hippocampal formation to the anterior thalamic nuclei

Dillingham, Christopher M., Erichsen, Jonathan T. ORCID: https://orcid.org/0000-0003-1545-9853, O'Mara, Shane M., Aggleton, John P. ORCID: https://orcid.org/0000-0002-5573-1308 and Vann, Seralynne D. ORCID: https://orcid.org/0000-0002-6709-8773 2015. Fornical and non-fornical projections from the rat hippocampal formation to the anterior thalamic nuclei. Hippocampus 25 (9) , pp. 977-992. 10.1002/hipo.22421

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Abstract

The hippocampal formation and anterior thalamic nuclei form part of an interconnected network thought to support memory. A central pathway in this mnemonic network comprises the direct projections from the hippocampal formation to the anterior thalamic nuclei, projections that, in the primate brain, originate in the subicular cortices to reach the anterior thalamic nuclei by way of the fornix. In the rat brain, additional pathways involving the internal capsule have been described, linking the dorsal subiculum to the anteromedial thalamic nucleus, as well as the postsubiculum to the anterodorsal thalamic nucleus. Confirming such pathways is essential in order to appreciate how information is transferred from the hippocampal formation to the anterior thalamus and how it may be disrupted by fornix pathology. Accordingly, in the present study, pathway tracers were injected into the anterior thalamic nuclei and the dorsal subiculum of rats with fornix lesions. Contrary to previous descriptions, projections from the subiculum to the anteromedial thalamic nucleus overwhelmingly relied on the fornix. Dorsal subiculum projections to the majority of the anteroventral nucleus also predominantly relied on the fornix, although postsubicular inputs to the lateral dorsal part of the anteroventral nucleus, as well as to the anterodorsal and laterodorsal thalamic nuclei, largely involved a non-fornical pathway, via the internal capsule.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences Psychology Neuroscience and Mental Health Research Institute (NMHRI) Medicine
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RF Otorhinolaryngology
Uncontrolled Keywords:	anatomy; fornix; hippocampus; memory; postsubiculum; subiculum
Additional Information:	This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Publisher:	Wiley
ISSN:	1050-9631
Funders:	Wellcome Trust
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	15 January 2015
Last Modified:	07 Nov 2023 11:19
URI:	https://orca.cardiff.ac.uk/id/eprint/69690

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