Muller, Simon T. R., Murat, Aurélien, Maillos, Delphine, Lesimple, Patrick, Hellier, Paul and Wirth, Thomas ![]() |
Abstract
A powerful new continuous process for the formation and use of donor/acceptor-substituted carbenes is described. The safety profile of diazo group transfer on methyl phenylacetate was determined including kinetic studies in batch and in flow using in-line IR analysis. Batch work-up and liquid chromatography were circumvented by developing an optimized liquid/liquid flow separation method providing aryl diazoacetates in high purity. Fast screening of reaction conditions in flow with in-line IR analysis allowed rapid reaction optimization. Finally, a multistep process of diazo group transfer, extraction, separation and subsequent diazo decomposition combined with multiple X[BOND]H insertion reactions was established.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Subjects: | Q Science > QD Chemistry |
Publisher: | Wiley |
ISSN: | 0947-6539 |
Last Modified: | 28 Oct 2022 08:44 |
URI: | https://orca.cardiff.ac.uk/id/eprint/71953 |
Citation Data
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