Consensus Paper: Neuroimmune mechanisms of cerebellar ataxias

Mitoma, Hiroshi, Adhikari, Keya, Aeschlimann, Daniel ORCID: https://orcid.org/0000-0003-0930-7706, Chattopadhyay, Partha, Hadjivassiliou, Marios, Hampe, Christiane S, Honnorat, Jerome, Joubert, Bastien, Kakei, Shinj, Lee, Jongho, Manto, Mario, Matsunaga, Akiko, Mizusawa, Hidehiro, Nanri, Kazunori, Shanmugarajah, Priya, Yoneda, Makoto and Yuki, Nobuhiro 2016. Consensus Paper: Neuroimmune mechanisms of cerebellar ataxias. Cerebellum 15 (2) , pp. 213-232. 10.1007/s12311-015-0664-x

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Abstract

In the last few years, a lot of publications suggested that disabling cerebellar ataxias may develop through immune-mediated mechanisms. In this consensus paper, we discuss the clinical features of the main described immune-mediated cerebellar ataxias and address their presumed pathogenesis. Immune-mediated cerebellar ataxias include cerebellar ataxia associated with anti-GAD antibodies, the cerebellar type of Hashimoto’s encephalopathy, primary autoimmune cerebellar ataxia, gluten ataxia, Miller Fisher syndrome, ataxia associated with systemic lupus erythematosus, and paraneoplastic cerebellar degeneration. Humoral mechanisms, cell-mediated immunity, inflammation, and vascular injuries contribute to the cerebellar deficits in immune-mediated cerebellar ataxias.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information:	Available under Open Access
Publisher:	Springer
ISSN:	1473-4222
Funders:	Bardhan Research and Education Trust of Rotherham, Ryder Briggs Trust
Last Modified:	28 Oct 2022 08:48
URI:	https://orca.cardiff.ac.uk/id/eprint/72207

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