Gamma linolenic acid inhibits tyrosine phosphorylation of focal adhesion kinase and paxillin and tumour cell matrix interaction

Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111, Hiscox, S., Puntis, Malcolm, Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X, Bryce, R., Horrobin, D. and Mansel, Robert Edward ORCID: https://orcid.org/0000-0002-8051-0726 1996. Gamma linolenic acid inhibits tyrosine phosphorylation of focal adhesion kinase and paxillin and tumour cell matrix interaction. International Journal of Oncology 8 (3) , pp. 583-587. 10.3892/ijo.8.3.583

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Abstract

Gamma linolenic acid (GLA) is an anti-cancer agent recently reported to inhibit tumour cell-matrix attachment. This study examined the effects of GLA on the adhesion of two tumour cell lines, HT115 (human colon) and MDA MB 231 (human breast), to an extracellular matrix, Matrigel. The action of GLA on focal adhesion kinase(FAK) and paxillin was also investigated. Following cell adhesion to Matrigel in control experiments, both FAK and paxillin were quickly tyrosine phosphorylated and become concentrated at focal adhesion areas. Inclusion of GLA resulted in an inhibition of the tyrosine phosphorylation of both FAK and paxillin leading to a reduced attachment of both cell types to Matrigel. FAK and paxillin were also less well distributed in the focal adhesions compared with the controls. It is concluded, therefore, that GLA inhibits tumour-matrix adhesion via the inhibition of FAK and paxillin tyrosine phosphorylation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Additional Information:	Full Text Sources Ingenta plc Spandidos Publications - PDF Other Literature Sources COS Scholar Universe Access more work from the authors - ResearchGate
Publisher:	Spandidos Publications
ISSN:	1019-6439
Last Modified:	15 Nov 2022 11:49
URI:	https://orca.cardiff.ac.uk/id/eprint/72593

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