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Molecular and cellular mechanisms of dopamine-mediated behavioral plasticity in the striatum

Cerovic, Milica, d'Isa, Raffaele, Tonini, Raffaella and Brambilla, Riccardo 2013. Molecular and cellular mechanisms of dopamine-mediated behavioral plasticity in the striatum. Neurobiology of Learning and Memory 105 , pp. 63-80. 10.1016/j.nlm.2013.06.013

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The striatum is the input structure of the basal ganglia system. By integrating glutamatergic signals from cortical and subcortical regions and dopaminergic signals from mesolimbic nuclei the striatum functions as an important neural substrate for procedural and motor learning as well as for reward-guided behaviors. In addition, striatal activity is significantly altered in pathological conditions in which either a loss of dopamine innervation (Parkinson’s disease) or aberrant dopamine-mediated signaling (drug addiction and L-DOPA induced dyskinesia) occurs. Here we discuss cellular mechanisms of striatal synaptic plasticity and aspects of cell signaling underlying striatum-dependent behavior, with a major focus on the neuromodulatory action of the endocannabinoid system and on the role of the Ras–ERK cascade.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QR Microbiology
Uncontrolled Keywords: Striatum; Nucleus accumbens; Basal ganglia; Long-term potentiation; Long-term depression; Instrumental learning; L-DOPA induced dyskinesia; Drug addiction; Ras–ERK signaling; Endocannabinoids
Publisher: Elsevier
ISSN: 1074-7427
Last Modified: 04 Jun 2017 08:05

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