Inhibition of motility and invasion of human lung cancer cells by invasion inhibiting factor 2

Han, Z.G., Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111, Hiscox, S., Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X, Isoai, A. and Mansel, Robert Edward ORCID: https://orcid.org/0000-0002-8051-0726 1996. Inhibition of motility and invasion of human lung cancer cells by invasion inhibiting factor 2. Surgical Oncology 5 (2) , pp. 77-84. 10.1016/S0960-7404(96)80004-1

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Abstract

The motility and invasion of cancer cells are basic requirements for the establishment of distant metastases. In this study, we examined the effect of invasion inhibiting factor 2 (IIF2), a motility/invasion regulatory agent, on the motility, invasion, growth and basement membrane attachment of human lung cancer cells. IIF2 significantly reduced cell dissociation, colony scattering and invasion induced by the motogenic factor, HGF/SF. Western and Northern analyses showed these cells to be positive for the HGF/SF receptor c-met. These effects were blocked by an anti-IIF2 antibody. IIF2 did not affect the growth and attachment of lung cancer cells to the basement membrane. It is concluded therefore that invasion inhibiting factor 2 is an inhibitor of human lung cancer cell motility and invasion in vitro and this may bear some importance in the construction of anti-metastatic therapies.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0960-7404
Last Modified:	15 Dec 2023 07:18
URI:	https://orca.cardiff.ac.uk/id/eprint/73142

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