Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study

Morgan, Kelly ORCID: https://orcid.org/0000-0002-8685-1177, Rahman, M., Atkinson, M., Zhou, S. M., Hill, R., Khanom, A., Paranjothy, S. and Brophy, S. 2013. Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study. Plos One 8 (11) , e79803. 10.1371/journal.pone.0079803

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Abstract

BACKGROUND:This study examines the effect of diabetes in pregnancy on offspring weight at birth and ages 1 and 5 years. METHODS:A population-based electronic cohort study using routinely collected linked healthcare data. Electronic medical records provided maternal diabetes status and offspring weight at birth and ages 1 and 5 years (n = 147,773 mother child pairs). Logistic regression models were used to obtain odds ratios to describe the association between maternal diabetes status and offspring size, adjusted for maternal pre-pregnancy weight, age and smoking status. FINDINGS:We identified 1,250 (0.9%) pregnancies with existing diabetes (27.8% with type 1 diabetes), 1,358 with gestational diabetes (0.9%) and 635 (0.4%) who developed diabetes post-pregnancy. Children whose mothers had existing diabetes were less likely to be large at 12 months (OR: 0.7 (95%CI: 0.6, 0.8)) than those without diabetes. Maternal diabetes was associated with high weight at age 5 years in children whose mothers had a high pre-pregnancy weight tertile (gestational diabetes, (OR:2.1 (95%CI:1.25-3.6)), existing diabetes (OR:1.3 (95%CI:1.0 to 1.6)). CONCLUSION:The prevention of childhood obesity should focus on mothers with diabetes with a high maternal pre-pregnancy weight. We found little evidence that diabetes in pregnancy leads to long term obesity 'programming'.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Research Institutes & Centres > Centre For Development and Evaluation of Complex Interventions for Public Health Improvement (DECIPHer) Schools > Social Sciences (Includes Criminology and Education)
Additional Information:	Pdf uploaded in accordance with publisher's policies at http://www.sherpa.ac.uk/romeo/issn/1932-6203/ (accessed 22.5.15).
Publisher:	Public Library of Science
ISSN:	1932-6203
Date of First Compliant Deposit:	30 March 2016
Last Modified:	28 Oct 2022 09:08
URI:	https://orca.cardiff.ac.uk/id/eprint/73452

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