Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis

Frugtniet, Bethan, Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 and Martin, Tracey Amanda ORCID: https://orcid.org/0000-0003-2690-4908 2015. Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis. Breast Cancer: Targets and Therapy 2015 (7) , pp. 99-109. 10.2147/BCTT.S59006

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Abstract

The Wiskott–Aldrich syndrome protein (WASP) and WASP family verprolin-homologous protein (WAVE) family are a group of molecules that form a key link between GTPases and the actin cytoskeleton. The role of WASP/WAVE family proteins in the control of actin polymerization through activation of the actin-related protein 2/3 complex is critical in the formation of the actin-based membrane protrusions seen in cell migration and invasion. For this reason, the activity of the WASP/WAVE family in cancer cell invasion and migration has been of great interest in recent years. Many reports have highlighted the potential of targeting the WASP/WAVE family as a therapy for the prevention of cancer progression, in particular breast cancer. This review focuses on the role of the WASP/WAVE family in breast cancer cell invasion and migration and how this relates to the molecular mechanisms of WASP/WAVE activity, their exact contributions to the stages of cancer progression, and how this can lead to the development of anticancer drugs that target the WASP/WAVE family and related pathways.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher:	Dove Medical Press
ISSN:	1179-1314
Date of Acceptance:	23 January 2015
Last Modified:	28 Oct 2022 09:11
URI:	https://orca.cardiff.ac.uk/id/eprint/73673

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