Ketamine amplifies induced gamma frequency oscillations in the human cerebral cortex

Shaw, Alexander D. ORCID: https://orcid.org/0000-0001-5741-7526, Saxena, Neeraj ORCID: https://orcid.org/0000-0003-0913-9351, Jackson, Laura E., Hall, Judith E. ORCID: https://orcid.org/0000-0002-6770-7372, Singh, Krish D. ORCID: https://orcid.org/0000-0002-3094-2475 and Muthukumaraswamy, Suresh D. ORCID: https://orcid.org/0000-0001-7042-3920 2015. Ketamine amplifies induced gamma frequency oscillations in the human cerebral cortex. European Neuropsychopharmacology 25 (8) , pp. 1136-1146. 10.1016/j.euroneuro.2015.04.012

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Abstract

At subanaesthetic doses, ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has demonstrated remarkable and rapid antidepressant efficacy in patients with treatment-resistant depression. The mechanism of action of ketamine is complex and not fully understood, with altered glutamatergic function and alterations of high-frequency oscillatory power (Wood et al., 2012) noted in animal studies. Here we used magnetoencephalography (MEG) in a single blind, crossover study to assess the neuronal effects of 0.5 mg/kg intravenous ketamine on task-related high-frequency oscillatory activity in visual and motor cortices. Consistent with animal findings, ketamine increased beta amplitudes, decreased peak gamma frequency in visual cortex and significantly amplified gamma-band amplitudes in motor and visual cortices. The amplification of gamma-band activity has previously been linked in animal studies to cortical pyramidal cell disinhibition. This study provides direct translatable evidence of this hypothesis in humans, which may underlie the anti-depressant actions of ketamine.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI) Cardiff University Brain Research Imaging Centre (CUBRIC)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Ketamine; Gamma oscillations; NMDA receptor; Magnetoencephalography; Visual cortex; Motor cortex
Publisher:	Elsevier
ISSN:	0924-977X
Date of Acceptance:	10 April 2015
Last Modified:	23 May 2024 01:13
URI:	https://orca.cardiff.ac.uk/id/eprint/73834

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