Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

[18F]6-fluoro-3,4-dihydroxy-l-phenylalanine - recent modern syntheses for an elusive radiotracer

Edwards, Richard and Wirth, Thomas 2015. [18F]6-fluoro-3,4-dihydroxy-l-phenylalanine - recent modern syntheses for an elusive radiotracer. Journal of Labelled Compounds and Radiopharmaceuticals 58 (5) , pp. 183-187. 10.1002/jlcr.3285

Full text not available from this repository.


[18F]6-fluoro-3,4-dihydroxy- l-phenylalanine ([18F]F-DOPA) has been known to be a useful radiotracer for over 30 years. Its widespread clinical use has been hampered by the lack of a robust, high yielding synthesis. This review summarises new developments in radiochemistry that are providing solutions to long standing problems involved in the synthesis of this important but elusive radiotracer. Considerable advances in nucleophilic synthesis have been achieved by optimising multistep strategies and using both hypervalent iodine chemistry and transition metal-mediated fluorinations allowing for the production of high specific activity [18F]F-DOPA.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Additional Information: Article first published online: 16 APR 2015
Publisher: Wiley-Blackwell
ISSN: 0362-4803
Date of Acceptance: 5 March 2015
Last Modified: 04 Jun 2017 08:11

Citation Data

Cited 15 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item