Antibiotic prescribing and associated diarrhoea: a prospective cohort study of care home residents

Gillespie, David ORCID: https://orcid.org/0000-0002-6934-2928, Hood, Kerenza ORCID: https://orcid.org/0000-0002-5268-8631, Bayer, Antony James ORCID: https://orcid.org/0000-0002-7514-248X, Carter, Ben Richard, Duncan, D., Espinasse, Aude, Evans, Meirion Rhys ORCID: https://orcid.org/0000-0003-3578-1866, Nuttall, Jacqueline, Stanton, Helen, Acharjya, A., Allen, S., Cohen, D., Groves, S., Francis, Nicholas Andrew ORCID: https://orcid.org/0000-0001-8939-7312, Howe, R., Johansen, A., Mantzourani, Efthymia D. ORCID: https://orcid.org/0000-0002-6313-1409, Thomas-Jones, Emma ORCID: https://orcid.org/0000-0001-7716-2786, Toghill, A., Wood, Fiona ORCID: https://orcid.org/0000-0001-7397-4074, Wigglesworth, Neil, Wootton, Mandy and Butler, Christopher Collet ORCID: https://orcid.org/0000-0002-0102-3453 2015. Antibiotic prescribing and associated diarrhoea: a prospective cohort study of care home residents. Age and Ageing 44 (5) , pp. 853-860. 10.1093/ageing/afv072

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Abstract

Background: the risk factors for and frequency of antibiotic prescription and antibiotic-associated diarrhoea (AAD) among care home residents are unknown. Aim: to prospectively study frequency and risks for antibiotic prescribing and AAD for care home residents. Design and setting: a 12-month prospective cohort study in care homes across South Wales. Method: antibiotic prescriptions and the development of AAD were recorded on case report forms. We defined AAD as three or more loose stools in a 24-h period occurring within 8 weeks of exposure to an antibiotic. Results: we recruited 279 residents from 10 care homes. The incidence of antibiotic prescriptions was 2.16 prescriptions per resident year (95% CI: 1.90–2.46). Antibiotics were less likely to be prescribed to residents from dual-registered homes (OR compared with nursing homes: 0.38, 95% CI: 0.18–0.79). For those who were prescribed antibiotics, the incidence of AAD was 0.57 episodes per resident year (95% CI: 0.41–0.81 episodes). AAD was more likely in residents who were prescribed co-amoxiclav (hazards ratio, HR = 2.08, 95% confidence interval, CI: 1.18–3.66) or routinely used incontinence pads (HR = 2.54, 95% CI: 1.26–5.13) and less likely in residents from residential homes (HR compared with nursing homes: 0.14, 95% CI: 0.06–0.32). Conclusion: residents of care homes, particularly of nursing homes, are frequently prescribed antibiotics and often experience diarrhoea following such prescriptions. Co-amoxiclav is associated with greater risk of AAD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine Pharmacy Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RM Therapeutics. Pharmacology
Publisher:	Oxford University Press
ISSN:	0002-0729
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	7 June 2015
Last Modified:	06 Nov 2024 23:45
URI:	https://orca.cardiff.ac.uk/id/eprint/74141

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