Neural and behavioral epigenetics; what it is, and what is hype

Isles, Anthony Roger ORCID: https://orcid.org/0000-0002-7587-5712 2015. Neural and behavioral epigenetics; what it is, and what is hype. Genes, Brain and Behavior 14 (1) , pp. 64-72. 10.1111/gbb.12184

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Abstract

The ability to examine epigenetic mechanisms in the brain has become readily available over the last 20 years. This has led to an explosion of research and interest in neural and behavioral epigenetics. Of particular interest to researchers, and indeed the lay public, is the possibility that epigenetic processes, such as changes in DNA-methylation and histone modification, may provide a biochemical record of environmental effects. This has led to some fascinating insights into how molecular changes in the brain can control behavior. However, some of this research has also attracted controversy and, as is dealt with here, some overblown claims. This latter problem is partly linked to the shifting sands of what is defined as 'epigenetics'. In this review, I provide an overview of what exactly epigenetics is, and what is hype, with the aim of opening up a debate as to how this exciting field moves forward.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Neuroscience and Mental Health Research Institute (NMHRI) Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Wiley
ISSN:	1601-1848
Last Modified:	28 Oct 2022 09:30
URI:	https://orca.cardiff.ac.uk/id/eprint/74773

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