Rescue of long-term memory after reconsolidation blockade

Trent, Simon ORCID: https://orcid.org/0000-0001-9563-4281, Barnes, Philip, Hall, Jeremy ORCID: https://orcid.org/0000-0003-2737-9009 and Thomas, Kerrie L. ORCID: https://orcid.org/0000-0003-3355-9583 2015. Rescue of long-term memory after reconsolidation blockade. Nature Communications 6 , 7897. 10.1038/ncomms8897

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Abstract

Memory reconsolidation is considered to be the process whereby stored memories become labile on recall, allowing updating. Blocking the restabilization of a memory during reconsolidation is held to result in a permanent amnesia. The targeted knockdown of either Zif268 or Arc levels in the brain, and inhibition of protein synthesis, after a brief recall results in a non-recoverable retrograde amnesia, known as reconsolidation blockade. These experimental manipulations are seen as key proof for the existence of reconsolidation. However, here we demonstrate that despite disrupting the molecular correlates of reconsolidation in the hippocampus, rodents are still able to recover contextual memories. Our results challenge the view that reconsolidation is a separate memory process and instead suggest that the molecular events activated initially at recall act to constrain premature extinction.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine Neuroscience and Mental Health Research Institute (NMHRI) MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Additional Information:	This work is licensed under a Creative Commons Attribution 4.0 International License.
Publisher:	Nature Research
ISSN:	2041-1723
Funders:	BBSRC, MRC
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	24 June 2015
Last Modified:	07 May 2023 10:49
URI:	https://orca.cardiff.ac.uk/id/eprint/75395

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