The domestication of the probiotic bacterium Lactobacillus acidophilus

Bull, Matthew J., Jolley, Keith A., Bray, James E., Aerts, Maarten, Vandamme, Peter, Maiden, Martin C. J., Marchesi, Julian Roberto ORCID: https://orcid.org/0000-0002-7994-5239 and Mahenthiralingam, Eshwar ORCID: https://orcid.org/0000-0001-9014-3790 2014. The domestication of the probiotic bacterium Lactobacillus acidophilus. Scientific Reports 4 , 7202. 10.1038/srep07202

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Abstract

Lactobacillus acidophilus is a Gram-positive lactic acid bacterium that has had widespread historical use in the dairy industry and more recently as a probiotic. Although L. acidophilus has been designated as safe for human consumption, increasing commercial regulation and clinical demands for probiotic validation has resulted in a need to understand its genetic diversity. By drawing on large, well-characterised collections of lactic acid bacteria, we examined L. acidophilus isolates spanning 92 years and including multiple strains in current commercial use. Analysis of the whole genome sequence data set (34 isolate genomes) demonstrated L. acidophilus was a low diversity, monophyletic species with commercial isolates essentially identical at the sequence level. Our results indicate that commercial use has domesticated L. acidophilus with genetically stable, invariant strains being consumed globally by the human population.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Nature Publishing Group
ISSN:	2045-2322
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	6 November 2014
Last Modified:	05 May 2023 12:56
URI:	https://orca.cardiff.ac.uk/id/eprint/75687

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