Type II transmembrane serine protease (TTSP) deregulation in cancer

Webb, Siobhan L., Sanders, Andrew James ORCID: https://orcid.org/0000-0002-7997-5286, Mason, Malcolm David ORCID: https://orcid.org/0000-0003-1505-2869 and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2011. Type II transmembrane serine protease (TTSP) deregulation in cancer. Frontiers in Bioscience 16 , pp. 539-552.

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Abstract

The Type II transmembrane serine proteases (TTSP) are a relatively newly identified family of proteolytic enzymes that have become the subject of intense scrutiny in the field of cancer research. Advances in genome screening technology have enabled the identification of putative members and the further characterization of existing members. The TTSPs are involved in a diverse range of physiological functions and new roles continue to be discovered. A large majority of these proteases appear to play crucial roles in the development of disease, especially cancer development and progression. This review presents the current knowledge of the biological role of those TTSPs that have been identified in the development and progression of human cancers.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher:	Frontiers in Bioscience
ISSN:	1093-9946
Last Modified:	28 Oct 2022 10:15
URI:	https://orca.cardiff.ac.uk/id/eprint/77528

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