Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Ion flux in the lung: virus-induced inflammasome activation

Triantafilou, Kathy ORCID: https://orcid.org/0000-0002-7473-6278 and Triantafilou, Martha ORCID: https://orcid.org/0000-0002-8489-2602 2014. Ion flux in the lung: virus-induced inflammasome activation. Trends in Microbiology 22 (10) , pp. 580-588. 10.1016/j.tim.2014.06.002

Full text not available from this repository.

Abstract

Innate immunity has a primary role in lung antimicrobial defenses. The inflammasome has evolved for this purpose and is an important surveillance system that, when triggered, fights infection and eliminates pathogens. However, there is growing evidence that the inflammasome also plays a role in the pathogenesis of acute and chronic respiratory disease. Inflammasomes contribute to both the clearance of the pathogen as well as its pathogenesis – depending on the amount of inflammation triggered. How respiratory viruses trigger inflammasome activation remains unclear. Emerging evidence shows that ion flux is responsible for triggering inflammasome activation in the lung, causing lung pathology and disease exacerbations. Viroporins, encoded by all common respiratory viruses, are responsible for the changes in intracellular ion homeostasis that modulate inflammasome activation. This is a novel mechanism by which respiratory viral infection activates inflammasomes, and identifies sensing of disturbances in intracellular ionic concentrations as a novel pathogen-recognition pathway in the lung.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QR Microbiology
Publisher: Elsevier
ISSN: 0966-842X
Last Modified: 28 Oct 2022 10:36
URI: https://orca.cardiff.ac.uk/id/eprint/78970

Citation Data

Cited 31 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item