Do statins have a role in the promotion of postoperative wound healing in cardiac surgical patients?

Fitzmaurice, Gerard J., McWilliams, Billy, Nölke, Lars, Redmond, J. Mark, McGuinness, Jonathan G. and O'Donnell, Mark E. 2014. Do statins have a role in the promotion of postoperative wound healing in cardiac surgical patients? Annals of Thoracic Surgery 98 (2) , pp. 756-764. 10.1016/j.athoracsur.2014.02.089

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Abstract

Cardiac surgical patients often have associated comorbidities that can impede normal wound healing; however, statin therapy has the potential to improve this process through augmentation of the normal inflammatory response. Outcomes included a 30% earlier rate of wound epithelialization and an 80% greater wound-breaking strength combined with faster wound healing rates (13.0 days vs 18.7 days, p < 0.0001). Inhibition of farnesyl pyrophosphate may hold a key role in the mediation of such advantageous effects. This systematic review suggests that there is sufficient evidence to warrant completion of a human trial to assess the effects of statins on wound healing.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RD Surgery
Publisher:	Elsevier
ISSN:	0003-4975
Last Modified:	27 Mar 2019 11:24
URI:	https://orca.cardiff.ac.uk/id/eprint/79006

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