Ibrahim, Ramez, Kalhan, Atul, Lammie, Alistair, Kotonya, Christine, Nannapanenni, Ravindra and Rees, Dafydd Rees  ORCID: https://orcid.org/0000-0002-1165-9092
2014.
Dense calcification in a GH-secreting pituitary macroadenoma.
Endocrinology, Diabetes & Metabolism Case Reports
, EDM130079.
10.1530/EDM-13-0079
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Abstract
A 30-year-old female presented with a history of secondary amenorrhoea, acromegalic features and progressive visual deterioration. She had elevated serum IGF1 levels and unsuppressed GH levels after an oral glucose tolerance test. Magnetic resonance imaging revealed a heterogeneously enhancing space-occupying lesion with atypical extensive calcification within the sellar and suprasellar areas. Owing to the extent of calcification, the tumour was a surgical challenge. Postoperatively, there was clinical, radiological and biochemical evidence of residual disease, which required treatment with a somatostatin analogue and radiotherapy. Mutational analysis of the aryl hydrocarbon receptor-interacting protein (AIP) gene was negative. This case confirms the relatively rare occurrence of calcification within a pituitary macroadenoma and its associated management problems. The presentation, biochemical, radiological and pathological findings are discussed in the context of the relevant literature.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | R Medicine > R Medicine (General) |
| Publisher: | BioScientifica |
| ISSN: | 2052-0573 |
| Date of First Compliant Deposit: | 16 September 2019 |
| Date of Acceptance: | 23 January 2014 |
| Last Modified: | 11 Oct 2023 18:35 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/79219 |
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