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Antimalarial properties of green tea

Sannella, Anna Rosa, Messori, Luigi, Casini, Angela, Vincieri, Franco Francesco, Bilia, Anna Rita, Majori, Giancarlo and Severini, Carlo 2007. Antimalarial properties of green tea. Biochemical and Biophysical Research Communications 353 (1) , pp. 177-181. 10.1016/j.bbrc.2006.12.005

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We show here that a crude extract of green tea as well as two of its main constituents, epigallocatechin-3-gallate (EGCG) and epicatechin gallate (ECG), strongly inhibit Plasmodium falciparum growth in vitro. Both these catechins are found to potentiate the antimalarial effects of artemisinin without interfering with the folate pathway. The importance of these findings and their mechanistic implications are discussed in view of future therapeutic strategies.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Elsevier
Last Modified: 23 Jul 2020 01:46

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