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NMDA receptor gene variations as modifiers in Huntington disease: a replication study

Saft, Carsten, Epplen, Jörg T., Wieczorek, Stefan, Landwehrmeyer, G. Bernhard, Roos, Raymund A.C., de Yebenes, Justo Garcia, Dose, Matthias, Tabrizi, Sarah J, Craufurd, David, Arning, Larissa, Bisson, Jonathan Ian and Rosser, Anne Elizabeth 2011. NMDA receptor gene variations as modifiers in Huntington disease: a replication study. PLoS Currents 3 , RRN1247. 10.1371/currents.RRN1247

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Several candidate modifier genes which, in addition to the pathogenic CAG repeat expansion, influence the age at onset (AO) in Huntington disease (HD) have already been described. The aim of this study was to replicate association of variations in the N-methyl D-aspartate receptor subtype genes GRIN2A and GRIN2B in the "REGISTRY" cohort from the European Huntington Disease Network (EHDN). The analyses did replicate the association reported between the GRIN2A rs2650427 variation and AO in the entire cohort. Yet, when subjects were stratified by AO subtypes, we found nominally significant evidence for an association of the GRIN2A rs1969060 variation and the GRIN2B rs1806201 variation. These findings further implicate the N-methyl D-aspartate receptor subtype genes as loci containing variation associated with AO in HD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Additional Information: Jonathan Bisson and Anne Rosser are collaborators on this article.
Publisher: PLoS
ISSN: 2157-3999
Last Modified: 06 Jul 2019 01:54

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