Hebbian and homeostatic plasticity mechanisms in regular spiking and intrinsic bursting cells of cortical layer 5

Greenhill, Stuart David ORCID: https://orcid.org/0000-0002-5038-5258, Ranson, Adam ORCID: https://orcid.org/0000-0002-4804-0832 and Fox, Kevin ORCID: https://orcid.org/0000-0002-2563-112X 2015. Hebbian and homeostatic plasticity mechanisms in regular spiking and intrinsic bursting cells of cortical layer 5. Neuron 88 (3) , pp. 539-552. 10.1016/j.neuron.2015.09.025

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Abstract

Layer 5 contains the major projection neurons of the neocortex and is composed of two major cell types: regular spiking (RS) cells, which have cortico-cortical projections, and intrinsic bursting cells (IB), which have subcortical projections. Little is known about the plasticity processes and specifically the molecular mechanisms by which these two cell classes develop and maintain their unique integrative properties. In this study, we find that RS and IB cells show fundementally different experience-dependent plasticity processes and integrate Hebbian and homeostatic components of plasticity differently. Both RS and IB cells showed TNFα-dependent homeostatic plasticity in response to sensory deprivation, but IB cells were capable of a much faster synaptic depression and homeostatic rebound than RS cells. Only IB cells showed input-specific potentiation that depended on CaMKII autophosphorylation. Our findings demonstrate that plasticity mechanisms are not uniform within the neocortex, even within a cortical layer, but are specialized within subcircuits.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Biosciences Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > Q Science (General)
Additional Information:	This is an open access article under the terms of the CC-BY Attribution 4.0 International license.
Publisher:	Elsevier (Cell Press)
ISSN:	0896-6273
Funders:	MRC
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	14 September 2015
Last Modified:	10 Feb 2024 02:18
URI:	https://orca.cardiff.ac.uk/id/eprint/80514

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