The strength of the genetic effect. Is there room for an environmental influence in the aetiology of schizophrenia?

McGuffin, P, Asherson, P, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 and Farmer, A 1994. The strength of the genetic effect. Is there room for an environmental influence in the aetiology of schizophrenia? British Journal of Psychiatry 164 (5) , pp. 593-599. 10.1192/bjp.164.5.593

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Abstract

The evidence for a genetic contribution to schizophrenia is compelling. However, the pattern of inheritance is complex and it is usually assumed that environmental factors also have a role that will eventually be identified. We argue that this is not necessarily the case. While a hypothesis combining genetic diathesis with environmental stress cannot be disproved, it is also possible that 'non-genetic' factors consist entirely of stochastic events affecting gene expression or structure.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Schools > Medicine Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Royal College of Psychiatrists
ISSN:	0007-1250
Last Modified:	31 Oct 2022 09:18
URI:	https://orca.cardiff.ac.uk/id/eprint/80550

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