Ipsilateral cortical motor desynchronisation is reduced in benign epilepsy with centro-temporal spikes

Brindley, Lisa ORCID: https://orcid.org/0000-0002-6673-3800, Koelewijn, Loes ORCID: https://orcid.org/0000-0002-7890-171X, Kirby, Amanda, Williams, Natalie, Thomas, Marie, te Water-Naudé, Johann, Gibbon, Frances, Muthukumaraswamy, Suresh, Singh, Krish Devi ORCID: https://orcid.org/0000-0002-3094-2475 and Hamandi, Khalid 2016. Ipsilateral cortical motor desynchronisation is reduced in benign epilepsy with centro-temporal spikes. Clinical Neurophysiology 127 (2) , pp. 1147-1159. 10.1016/j.clinph.2015.08.020

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Abstract

Objective Magnetoencephalography (MEG) and a simple motor paradigm were used to study induced sensorimotor responses and their relationship to motor skills in children diagnosed with Benign Epilepsy with Centro-Temporal Spikes (BECTS). Methods Twenty-one children with BECTS and 15 age-matched controls completed a finger abduction task in MEG; movement-related oscillatory responses were derived and contrasted between groups. A subset of children also completed psycho-behavioural assessments. Regression analyses explored the relationship of MEG responses to manual dexterity performance, and dependence upon clinical characteristics. Results In children with BECTS, manual dexterity was below the population mean (p = .002) and three showed severe impairment. Our main significant finding was of reduced ipsilateral movement related beta desynchrony (MRBDi) in BECTS relative to the control group (p = .03) and predicted by epileptic seizure recency (p = .02), but not age, medication status, or duration of epilepsy. Laterality scores across the entire cohort indicated that less lateralised MRBD predicted better manual dexterity (p = .04). Conclusions Altered movement-related oscillatory responses in ipsilateral motor cortex were associated with motor skill deficits in children with BECTS. These changes were more marked in those with more recent seizures. Significance These findings may reflect differences in inter-hemispheric interactions during motor control in BECTS.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Psychology Neuroscience and Mental Health Research Institute (NMHRI) MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Development; BECTS; MEG; Movement; Oscillations
Publisher:	Elsevier
ISSN:	1388-2457
Funders:	The Waterloo Foundation
Date of Acceptance:	17 August 2015
Last Modified:	27 Oct 2022 01:09
URI:	https://orca.cardiff.ac.uk/id/eprint/80747

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